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  • New Experimental Probes for Enzyme Specificity and Mechanism : Volume 685
    New Experimental Probes for Enzyme Specificity and Mechanism : Volume 685

    New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.

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  • Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity
    Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity

    A concise and accessible textbook covering ligand-binding theory in chemistry, biology, and drug development In Ligand-binding Basics: Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity, accomplished chemist Jannette Carey introduces ligand binding in a thorough and practical way for those new to the topic, as well as anyone seeking a connection between theory and experiment.Using a minimum of mathematical formalism, this book offers analytical rigor while remaining accessible to non-specialist practitioners.It provides readers with the skills they need to analyze their own binding data or published results, helping them develop an intuitive grasp of ligand-binding phenomena integrated with structural and thermodynamic understanding.Topics covered include: Application of the principles of equilibrium, mass action, and mass balance to derive the basic equations that describe all binding processesRecommended approaches for plotting and graphical analysis of binding dataStrategies for designing, analyzing, interpreting, and troubleshooting experiments from the perspective of ligand-binding theoryReview of selected examples that illustrate integration of structural and thermodynamic analysis Perfect for students and educators in chemistry, biochemistry, molecular biology, and pharmaceutical science, Ligand-binding Basics will also appeal to practitioners who aim to study ligand binding in any molecular system.

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  • Autobiographical Memory Specificity and Psychopathology : A Special Issue of Cognition and Emotion
    Autobiographical Memory Specificity and Psychopathology : A Special Issue of Cognition and Emotion

    It has been repeatedly demonstrated that depression and reported history of trauma are associated with a difficulty in retrieving specific autobiographical memories, a phenomenon called overgeneral memory (Williams & Broadbent, 1986).Over the past twenty years there has been a stimulating progression in knowledge in this field, and it is clear that the topic has a considerable level of importance, both from a theoretical and clinical perspective.This Special Issue is intended to further advance this field which lies at the heart of the cognition-emotion interface.Papers published in this Issue address key issues relating to the underlying mechanisms and aetiology of overgeneral autobiographical memory, providing a state-of-the-art and pushing the field forward.

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  • Investing in Bonds For Dummies
    Investing in Bonds For Dummies

    Improve the strength of your portfolio with this straightforward guide to bond investing Investing in Bonds For Dummies introduces you to the basics you need to know to get started with bond investing.You’ll find details on understanding bond returns and risks, and recognizing the major factors that influence bond performance.Unlike some investing vehicles, bonds typically pay interest on a regular schedule, so you can use them to provide an income stream while you protect your capital.This easy-to-understand guide will show you how to incorporate bonds into a diversified portfolio and a solid retirement plan.Learn the ins and outs of buying and selling bonds and bond fundsUnderstand the risks and potential rewards in corporate bonds, government bonds, and beyondDiversify your portfolio by using bonds to balance stocks and other investmentsGain the fundamental information you need to make smart bond investment choicesThis Dummies investing guide is great for investors looking for a resource to help them understand, evaluate, and incorporate bonds into their current investment portfolios.

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  • What is the biosubstrate specificity of bonds?

    The biosubstrate specificity of bonds refers to the ability of enzymes to selectively bind to specific substrates and catalyze specific chemical reactions. Enzymes have specific active sites that are complementary to the shape and chemical properties of their substrates, allowing them to form temporary bonds and facilitate the conversion of substrates into products. This specificity is crucial for the regulation of biochemical pathways and the overall functioning of biological systems. It ensures that the right reactions occur at the right time and in the right place within the cell.

  • What are substrate specificity and activity specificity using the example of restriction enzymes?

    Substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. In the case of restriction enzymes, they have substrate specificity for particular DNA sequences, known as recognition sites. For example, the restriction enzyme EcoRI recognizes and binds to the DNA sequence GAATTC. Activity specificity, on the other hand, refers to the specific chemical reaction that an enzyme catalyzes. In the case of restriction enzymes, their activity specificity is to cleave the DNA at specific recognition sites. For example, EcoRI cleaves the DNA at the GAATTC sequence. In summary, substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule, while activity specificity refers to the specific chemical reaction that the enzyme catalyzes. In the case of restriction enzymes, they have substrate specificity for specific DNA sequences and activity specificity to cleave the DNA at those sequences.

  • What is the actual difference between catalytic specificity and substrate specificity in enzymes?

    Catalytic specificity refers to the ability of an enzyme to catalyze a specific chemical reaction, while substrate specificity refers to the ability of an enzyme to bind to a specific substrate. In other words, catalytic specificity is about the type of reaction that an enzyme can catalyze, while substrate specificity is about the specific molecule that an enzyme can bind to and act upon. Enzymes can have different levels of specificity for both their catalytic activity and their substrate binding, which allows them to carry out specific functions in the cell.

  • What is the substrate specificity of enzymes?

    The substrate specificity of enzymes refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. Enzymes are highly specific in their interactions with substrates, as they have active sites that are uniquely shaped to accommodate specific substrates. This specificity ensures that enzymes only catalyze specific reactions and do not interact with other molecules in the cell. Substrate specificity is crucial for the efficiency and regulation of biochemical reactions in living organisms.

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  • Moving Beyond Modern Portfolio Theory : Investing That Matters
    Moving Beyond Modern Portfolio Theory : Investing That Matters

    Moving Beyond Modern Portfolio Theory: Investing That Matters tells the story of how Modern Portfolio Theory (MPT) revolutionized the investing world and the real economy, but is now showing its age.MPT has no mechanism to understand its impacts on the environmental, social and financial systems, nor any tools for investors to mitigate the havoc that systemic risks can wreck on their portfolios.It’s time for MPT to evolve. The authors propose a new imperative to improve finance’s ability to fulfil its twin main purposes: providing adequate returns to individuals and directing capital to where it is needed in the economy.They show how some of the largest investors in the world focus not on picking stocks, but on mitigating systemic risks, such as climate change and a lack of gender diversity, so as to improve the risk/return of the market as a whole, despite current theory saying that should be impossible. "Moving beyond MPT" recognizes the complex relations between investing and the systems on which capital markets rely, "Investing that matters" embraces MPT’s focus on diversification and risk adjusted return, but understands them in the context of the real economy and the total return needs of investors.Whether an investor, an MBA student, a Finance Professor or a sustainability professional, Moving Beyond Modern Portfolio Theory: Investing That Matters is thought-provoking and relevant.Its bold critique shows how the real world already is moving beyond investing orthodoxy.

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  • Applied Fundamentals in Finance : Portfolio Management and Investments
    Applied Fundamentals in Finance : Portfolio Management and Investments

    This textbook provides a comprehensive introduction to portfolio management and investments.Focusing on four core areas – portfolio management, equities, bonds, and derivatives – it is primarily intended for undergraduate and graduate students alike.However, it will also benefit practitioners working in the fields of financial analysis and portfolio management and professionals who aspire to such professional activities in the financial industry.To ensure its high practical relevance, the book includes a host of case studies and examples from real-world practice, mainly from the German and Swiss financial markets.Additionally, the book shows how to implement the models in Microsoft Excel.

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  • Investing Explained : The Accessible Guide to Building an Investment Portfolio
    Investing Explained : The Accessible Guide to Building an Investment Portfolio

    Maximize your chances of investment success with this accessible and profitable guide which pulls away the curtain to put you on a level footing with the professionals - and points out where the pros can get it wrong.Never in history has it been easier for private investors to get involved in the market, and changes in technology, regulation and access to information mean that the advantage experts may have had is fast disappearing.Written by Matthew Partridge, a financial journalist for the UK's leading investment magazine, Investing Explained is filled with real life examples and plain English summaries of research produced by banks and academics to separate fact from fiction when it comes to investment clichés.Investing Explained covers the basics for beginner investors and includes more in-depth advice for those with more experience.Benefit from an overview of behavioural psychology (and how you can profit from the irrational behaviour of others), advice on fintech apps and cryptocurrencies, and the impact of a political or economic crisis on your investments.Access the stock market with this invaluable guide and build an investment portfolio which can secure your financial future.

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  • Advances in Active Portfolio Management: New Developments in Quantitative Investing
    Advances in Active Portfolio Management: New Developments in Quantitative Investing

    From the leading authorities in their field—the newest, most effective tools for avoiding common pitfalls while maximizing profits through active portfolio managementWhether you’re a portfolio managers, financial adviser, or student of investing, this follow-up to the authors’ classic work on the subject delivers everything you need to master the concepts and practices of active portfolio management. Advances in Active Portfolio Management brings you up to date on the issues, trends, and challenges in the world of active management and shows how advances in the authors’ approach can solve current problems.It includes articles published in top management journals and brand-new material covering: • Dynamic Analyses• Signal Weighting• Implementation Efficiency • Holdings-based attribution• Expected returns• Risk management• Portfolio construction• Fees Written in clear, engaging language, Advances in Active Portfolio Management make complex issues easy to understand and put into practice.It’s the one-stop resource you need to succeed in the world of investing today.

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  • What is the group specificity of enzymes?

    Group specificity of enzymes refers to the ability of an enzyme to act on a specific functional group within a substrate molecule. This means that the enzyme can only catalyze a reaction involving a particular functional group, such as an alcohol or an amine. Enzymes with group specificity are highly selective and only interact with substrates that contain the specific functional group that they are designed to act upon. This specificity is important for the regulation and control of biochemical pathways in living organisms.

  • What is the specificity of enzymes on substrates?

    Enzymes are highly specific in their interactions with substrates, meaning that each enzyme typically catalyzes a specific chemical reaction with a specific substrate. This specificity is due to the unique three-dimensional shape of the enzyme's active site, which is complementary to the shape and chemical properties of its specific substrate. The enzyme-substrate interaction is often compared to a lock and key, where the enzyme (lock) can only bind to its specific substrate (key) due to their precise matching shapes and chemical properties. This specificity ensures that enzymes can efficiently catalyze specific reactions without interfering with other cellular processes.

  • What does the term cell type specificity mean?

    Cell type specificity refers to the unique characteristics and functions of a particular type of cell within an organism. It means that certain cells are specialized to perform specific tasks or functions within the body, and they have distinct molecular and structural features that enable them to carry out these functions. This specificity allows for the coordination and regulation of various physiological processes within the organism, as different cell types can perform their specialized roles in a coordinated manner. Understanding cell type specificity is important for studying the development, function, and dysfunction of different tissues and organs in the body.

  • Could you please provide an urgent response regarding specificity of action?

    Specificity of action refers to the ability of a treatment or intervention to target a particular problem or condition without affecting other parts of the body. It is important to consider the specificity of action when choosing a treatment to ensure that it effectively addresses the intended issue without causing unnecessary side effects or harm to other areas. It is also important to consult with a healthcare professional to determine the most appropriate and specific treatment for a particular condition.

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