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  • Evolution, Composition and Regulation of Supernumerary B Chromosomes
    Evolution, Composition and Regulation of Supernumerary B Chromosomes

    Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi. Since their discovery more than a century ago, they have been a source of puzzlement, as they only occur in some members of a population and are absent from others. When they do occur, they are often harmful, and in the absence of “selfishness”, based on mechanisms of mitotic and meiotic drive, there appears to be no obvious reason for their existence. Cytogeneticists have long wrestled with questions about the biological existence of these enigmatic elements, including their lack of any adaptive properties, apparent absence of functional genes, their origin, sequence organization, and co-evolution as nuclear parasites. Emerging new technologies are now enabling researchers to step up a gear, to look enthusiastically beyond the previous limits of the horizon, and to uncover the secrets of these “silent” chromosomes. This book provides a comprehensive guide to theoretical advancements in the field of B chromosome research in both animal and plant systems. 

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  • Abnormal Chromosomes : The Past, Present, and Future of Cancer Cytogenetics
    Abnormal Chromosomes : The Past, Present, and Future of Cancer Cytogenetics

    Explore the past, present, and future of cancer cytogeneticsIn Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics, globally renowned researchers Drs.Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients.The book also discusses how cytogenetics – the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics. The book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders.From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process?How was information of this nature put to good use in the clinical management of cancer patients?Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics offers readers: A thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developedComprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancerA detailed chronological resume of cancer cytogenetic discoveries during the 20th centuryIn-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populationsA discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation.The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients.

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  • Investing in Bonds For Dummies
    Investing in Bonds For Dummies

    Improve the strength of your portfolio with this straightforward guide to bond investing Investing in Bonds For Dummies introduces you to the basics you need to know to get started with bond investing.You’ll find details on understanding bond returns and risks, and recognizing the major factors that influence bond performance.Unlike some investing vehicles, bonds typically pay interest on a regular schedule, so you can use them to provide an income stream while you protect your capital.This easy-to-understand guide will show you how to incorporate bonds into a diversified portfolio and a solid retirement plan.Learn the ins and outs of buying and selling bonds and bond fundsUnderstand the risks and potential rewards in corporate bonds, government bonds, and beyondDiversify your portfolio by using bonds to balance stocks and other investmentsGain the fundamental information you need to make smart bond investment choicesThis Dummies investing guide is great for investors looking for a resource to help them understand, evaluate, and incorporate bonds into their current investment portfolios.

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  • Moving Beyond Modern Portfolio Theory : Investing That Matters
    Moving Beyond Modern Portfolio Theory : Investing That Matters

    Moving Beyond Modern Portfolio Theory: Investing That Matters tells the story of how Modern Portfolio Theory (MPT) revolutionized the investing world and the real economy, but is now showing its age.MPT has no mechanism to understand its impacts on the environmental, social and financial systems, nor any tools for investors to mitigate the havoc that systemic risks can wreck on their portfolios.It’s time for MPT to evolve. The authors propose a new imperative to improve finance’s ability to fulfil its twin main purposes: providing adequate returns to individuals and directing capital to where it is needed in the economy.They show how some of the largest investors in the world focus not on picking stocks, but on mitigating systemic risks, such as climate change and a lack of gender diversity, so as to improve the risk/return of the market as a whole, despite current theory saying that should be impossible. "Moving beyond MPT" recognizes the complex relations between investing and the systems on which capital markets rely, "Investing that matters" embraces MPT’s focus on diversification and risk adjusted return, but understands them in the context of the real economy and the total return needs of investors.Whether an investor, an MBA student, a Finance Professor or a sustainability professional, Moving Beyond Modern Portfolio Theory: Investing That Matters is thought-provoking and relevant.Its bold critique shows how the real world already is moving beyond investing orthodoxy.

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  • Are a chromatid chromosome and two chromatid chromosomes homologous chromosomes or a set of chromosomes?

    A chromatid chromosome and two chromatid chromosomes are not homologous chromosomes, but rather a set of chromosomes. Homologous chromosomes are pairs of chromosomes that contain the same genes in the same order, one from each parent. In contrast, chromatid chromosomes are duplicated copies of a single chromosome that are joined together at the centromere. Two chromatid chromosomes refer to a duplicated chromosome in preparation for cell division.

  • Are chromosomes unreliable?

    Chromosomes are not inherently unreliable, as they are the structures that carry our genetic information and play a crucial role in cell division and inheritance. However, errors can occur during the process of chromosome replication and segregation, leading to genetic mutations and disorders. Additionally, environmental factors and lifestyle choices can also impact the stability and integrity of chromosomes. Overall, while chromosomes are essential for the functioning of our cells and the inheritance of genetic traits, they are not immune to errors and can be influenced by various factors.

  • What is the difference between single chromosomes and double chromosomes?

    Single chromosomes refer to a single strand of DNA that contains genetic information. In contrast, double chromosomes refer to a pair of identical chromosomes, one from each parent, that are joined together at the centromere. Single chromosomes are found in haploid cells, such as gametes, while double chromosomes are found in diploid cells, such as somatic cells. Double chromosomes allow for genetic diversity and the exchange of genetic material through processes such as meiosis and fertilization.

  • What is the difference between chromosomes, chromatids, and double chromosomes?

    Chromosomes are the structures within cells that contain genetic information. They are made up of DNA and proteins. Chromatids are the two identical copies of a chromosome that are formed during the process of DNA replication. Double chromosomes, on the other hand, refer to the paired chromosomes that are formed during cell division, with each chromosome consisting of two sister chromatids. In summary, chromosomes are the overall structures containing genetic material, chromatids are the individual copies of a chromosome, and double chromosomes are the paired chromosomes formed during cell division.

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  • Genetics 101 : From Chromosomes and the Double Helix to Cloning and DNA Tests, Everything You Need to Know about Genes
    Genetics 101 : From Chromosomes and the Double Helix to Cloning and DNA Tests, Everything You Need to Know about Genes

    A clear and straightforward explanation of genetics in this new edition of the popular 101 series.Our genetic makeup determines so much about who we are, and what we pass on to our children—from eye color, to height, to health, and even our longevity.Genetics 101 breaks down the science of how genes are inherited and passed from parents to offspring, what DNA is and how it works, how your DNA affects your health, and how you can use your personal genomics to find out more about who you are and where you come from. Whether you’re looking for a better scientific understanding of genetics, or looking into your own DNA, Genetics 101 is your go-to source to discover more about both yourself and your ancestry.

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  • Applied Fundamentals in Finance : Portfolio Management and Investments
    Applied Fundamentals in Finance : Portfolio Management and Investments

    This textbook provides a comprehensive introduction to portfolio management and investments.Focusing on four core areas – portfolio management, equities, bonds, and derivatives – it is primarily intended for undergraduate and graduate students alike.However, it will also benefit practitioners working in the fields of financial analysis and portfolio management and professionals who aspire to such professional activities in the financial industry.To ensure its high practical relevance, the book includes a host of case studies and examples from real-world practice, mainly from the German and Swiss financial markets.Additionally, the book shows how to implement the models in Microsoft Excel.

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  • Investing Explained : The Accessible Guide to Building an Investment Portfolio
    Investing Explained : The Accessible Guide to Building an Investment Portfolio

    Maximize your chances of investment success with this accessible and profitable guide which pulls away the curtain to put you on a level footing with the professionals - and points out where the pros can get it wrong.Never in history has it been easier for private investors to get involved in the market, and changes in technology, regulation and access to information mean that the advantage experts may have had is fast disappearing.Written by Matthew Partridge, a financial journalist for the UK's leading investment magazine, Investing Explained is filled with real life examples and plain English summaries of research produced by banks and academics to separate fact from fiction when it comes to investment clichés.Investing Explained covers the basics for beginner investors and includes more in-depth advice for those with more experience.Benefit from an overview of behavioural psychology (and how you can profit from the irrational behaviour of others), advice on fintech apps and cryptocurrencies, and the impact of a political or economic crisis on your investments.Access the stock market with this invaluable guide and build an investment portfolio which can secure your financial future.

    Price: 16.99 £ | Shipping*: 3.99 £
  • Advances in Active Portfolio Management: New Developments in Quantitative Investing
    Advances in Active Portfolio Management: New Developments in Quantitative Investing

    From the leading authorities in their field—the newest, most effective tools for avoiding common pitfalls while maximizing profits through active portfolio managementWhether you’re a portfolio managers, financial adviser, or student of investing, this follow-up to the authors’ classic work on the subject delivers everything you need to master the concepts and practices of active portfolio management. Advances in Active Portfolio Management brings you up to date on the issues, trends, and challenges in the world of active management and shows how advances in the authors’ approach can solve current problems.It includes articles published in top management journals and brand-new material covering: • Dynamic Analyses• Signal Weighting• Implementation Efficiency • Holdings-based attribution• Expected returns• Risk management• Portfolio construction• Fees Written in clear, engaging language, Advances in Active Portfolio Management make complex issues easy to understand and put into practice.It’s the one-stop resource you need to succeed in the world of investing today.

    Price: 93.99 £ | Shipping*: 0.00 £
  • Does a homologous pair of chromosomes consist of two single-chromatid chromosomes or two double-chromatid chromosomes?

    A homologous pair of chromosomes consists of two single-chromatid chromosomes. Each chromosome in the pair comes from one parent, and they carry the same genes in the same order, but may have different versions of those genes. During the S phase of the cell cycle, each single-chromatid chromosome replicates to form a double-chromatid chromosome, but these double-chromatid chromosomes do not pair up with each other during normal cell division.

  • What is the difference between chromatids, chromosomes, and pairs of chromosomes?

    Chromatids are two identical copies of a chromosome that are joined together at the centromere. Chromosomes are thread-like structures made of DNA and proteins that contain genetic information. Pairs of chromosomes refer to two homologous chromosomes, one inherited from each parent, that carry similar genes but may have different variations. In summary, chromatids are the duplicated copies of a single chromosome, chromosomes are the structures that contain genetic material, and pairs of chromosomes are homologous chromosomes inherited from each parent.

  • What is the difference between double chromosomes and homologous double chromosomes?

    Double chromosomes refer to a pair of identical chromosomes that are present in a diploid organism, one inherited from each parent. On the other hand, homologous double chromosomes are a pair of chromosomes that are similar in size, shape, and genetic content, but not identical. Homologous chromosomes carry the same genes in the same order, but may have different versions of those genes (alleles) due to genetic variation.

  • How do chromosomes spiralize?

    Chromosomes spiralize through a process called supercoiling. This occurs when the DNA double helix is twisted around itself, creating a more compact structure. Enzymes called topoisomerases are responsible for this process, helping to regulate the level of supercoiling in the chromosome. Supercoiling allows the long DNA molecule to be packaged into the small space of the cell nucleus, and also plays a role in regulating gene expression and DNA replication.

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